REGARDING BACLOFEN vs XYREM - effects on EEG on polysomnogram for nap and overnight... Here is an article that might be more convincing for doctors to prescribe Baclofen for Narcolepsy.
In short, Baclofen and Sodium Oxybate (Xyrem) have similarEEG patterns, showing similar effects on improving quality of sleep, but Baclofen has a delayed reaction and thus lasts longer... That's why, for me, it is more effective to take it an hour before bed, and why, for me, it isn't necessary to re-dose on Baclofen in the middle of the night... (I take Baclofen in combination with Temazepam an hour ahead of bed.)
This is a study performed on healthy adults, ages 20-26. The article is tedious to read, but if you use Evelyn Wood's Speed Reading method, you can get through it... Basically they did a double-blind study to compare Sodium Oxybate, Baclofen, and a placebo to see how they affect improvements in sleep...
I AM NOT SUGGESTING THAT ANYBODY QUIT XYREM IF IT IS SUCCESSFUL FOR YOU... It is just that many cannot take Xyrem for various reasons, and their doctors are reluctant to prescribe Baclofen...
Here is the article, published by NCBI, which is a reliable source for research information: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397788/
Baclofen is a muscle relaxer. It has been on the market for 50 years. There are no known harmful effects from being on it long-term.
……Baclofen is a GABAb receptor agonist, as is Xyrem, but chemically different from Xyrem. Baclofen is derived from GABA. Xyrem is derived from GHB.
…..GABAb receptor agonists stimulate the brain to make more GABAb, a brain chemical that signals the brain to make other chemicals necessary for quality sleep. Narcoleptic sleep is broken. We have fragmented sleep patterns, and many of us don’t go into the deeper stages of sleep. With the production of certain brain chemicals, the body is able to regulate the sleep patterns for a restful night’s sleep.
…..Repairing our broken sleep is a big factor in being able to stay awake during the day. Stimulant meds may still be necessary, but they are more effective with a good night’s (restful) sleep.
…..Many people are successful with Xyrem. It changes lives. I cannot take Xyrem for various reasons.
…..a great number of sleep specialists are unaware of Baclofen as an alternative to Xyrem, and they are reluctant or unwilling to prescribe it. There hasn’t been much research on Baclofen for narcolepsy… likely because it won’t make anybody rich… It costs $8 per month.
…..There is a MODIFIED version of Baclofen (R-Baclofen) that is currently being studied… so far only on lab-created narcoleptic mice. Results are promising so far. I hope they can put this drug on the fast-track for human use… (I took articles about R-Baclofen to my sleep doctor to help convince him to let me try Baclofen.)
…I take Baclofen in combination with Temazepam. Some people who are on Baclofen are not using any additional meds for sleep. As with any medication, it may not work for everybody. We all have our own unique body chemistry. That is why there are so many different types of meds being used for the treatment of Narcolepsy.
…..I still take Modafinil in the morning. I think it might be rare that a person could be successfully treated with a single medication. For many people, a combination of meds is necessary to “correct” the brain chemistry.
He wanted me to try Xyrem, but then we found that there were various reasons that it was contraindicated for me... I did the research and found Baclofen, and he agreed to let me try it...
I started taking Baclofen in September, for sleep, along with what I was already taking... Since adding Baclofen, my daytime wakefulness has improved to the point that I rarely need a nap during the day... I have joined the land of the living...
Previously, I needed two very long naps just to function in between... every single day... And I was a zombie... especially in the morning... much difficulty getting out of bed, and much difficulty remembering what I was supposed to do to get hubby's lunch and breakfast ready, so he could head out the door... even though it was the same every day...
Now, I don't have involuntary sleep attacks during the day... I fall asleep in the right order at night... no dreaming before falling asleep... and I don't really remember dreaming much, except in the morning, during the lighter sleep phase that happens when we are supposed to be transitioning from sleep to wake...
I am able to remember things... went shopping recently and had forgotten my grocery list... I remembered almost everything on it! Plus, I am able to successfully drive long distances!
For me it seems to have affected adderal a bit as well in that I can focus better, I am thinking I may be able to reduce dosage of it in the near future! I have found I am over focusing on things recently which is a nice change. And the longer I take it the better I seem to be doing.