Any nootropic out there to help with fibromyalgia? My mom is in pain all the time and very sluggish
Kratom helps the pain & fatigue. Temporary symptom relief, not a cure. Takes some trial and error to find the right dose & strain but well worth it. Still looking for a long term solution. Sucks needing pain relief 24/7.
It is a bit of trial and error.

However certain things can reduce pain overall:
Anti inflammatories
Epilepsy medications altering gated channels
More serotonin like antidepressants
More dopamine like stimulants
Sometimes sedative medications can help
Thyroid medication can be helpful sometimes
Anti leukotrine inhibitor (singulair)
SARMs in particular might help fibromyalgia

So there are a lot of options. It would be about trying many different things and find what works best for her.
As an adaptogen and immunomodulatory supplement the Reishi mushroom has been reported to help alleviate symptoms associated fibromyalgia.

I do not have any tincture now but plenty of dried Reishi (ganoderma tsugae) if you wanted to make your own or I'm processing some now that will be ready in about a week.

You can also find many sources online for reishi products also reddit gives a lot of helpful info. No stacks, just mushrooms. Full spectrum dual extracts are the most beneficial.

Here is some information I dug up..

"Reishi Mushrooms are effective for Fibromyalgia by reducing spasticity in muscles, Irritable Bowel Syndrome, Colitis, Ulcers, bronchial spasms and it helps to detoxify the liver."
I used tramadol recreationally 3-5 days a month the past 3 years. One of my all time favorite highs. The withdrawal is very nasty congratulations to your friend for kicking it. I find the pain killing effects from it unmatched, even by traditional Opioids. Hope someone else can chime in.
Nootropics are for cognitive enhancement, not pain.
Some of my patients sweat by CBD oil.. they say it gave them sleep and relief from pain that traditional medicine could not give
cbd oil cbd heavy bud or breast milk.

fibromyalgia comes from an improper functioning endo cannabinoid system .

the people here recommending opoids need to fuck off.
For what its worth from my personal perspective, it's more likely to be skeletal musculature related myalgia caused from post accute withdrawals not only associated with opioid receptor affinity but also the seretonergic actions from taking tramadol. One of the problems associated with many pharmaceuticals is the adaptations to the nociception (pain receptor) system.

A complete overhaul of nutrients & perhaps cbd's may help. Absolutely nothing with opiate actions will help, they will only hinder & prolong recovery. The serotonin system needs to be rebuilt with precursor amino's so amino acid therapy will help immensely.
Not saying this is the case. But if one drinks LOTS of diet soda. Aspertame poisoning can cause a fibronyalgia diagnoses.
Fibromyalgia is a garbage basket diagnosis. They have ruled everything else out so they toss your diagnosis in the garbage.

Let's see if we can determine if it is actually fibromyalgia.

Do zippers and seams of clothes hurt?

Do muscles and joints hurt?

Do only joints hurt?

Does the pain increase in the cold?

Pins and needles with the pain?

Burning or wet sensation with the pain?

Do they get zaps down their body?

Reynards syndrome?

Lots of Edema?

Can they bend their joints past normal locking position like knees or elbows? They pull their pinky backward to top of hand to either straight up or past closer to back of hand? Can their thumb touch their wrist on the same arm?
I have fibromyalgia, and i would say it is unfortunately a not well defined diagnosis; however, if you really know about the statistics of medicine, you know there are lots of diagnoses like that, and the fibro diagnosis at least helps researchers track a phenomenon that may have a singular cause, or it may have lots of different causes.

Alyssa , I would like to know where you get this list. I have all of those symptoms except edema; however, they have been associated with other diagnoses, for example, the hypermobility was diagnosed as Ehlers-Danlos syndrome, the Reynauds with Postural Othostatic Tachycardia syndrome, etc. Only the muscle pain alone went into the fibromyalgia diagnosis. However, I've seen a study showing a large proportion of people with fibromyalgia have orthostatic intolerance, and the recent study showing increased innervation in the hands explains the orthostatic intolerance, hence my conjecture that desensitizing those nerves could lead to improvement. Could also lead to decompensation though, but, mild shock to the brain and vagus nerves are already studied, and mild shock to the hands isn't likely to cause very much harm so I think it might be worth the study.
If using stimulants is giving you no luck, try focusing on your microbiome.

I've talked to people who have cured fatigue/brain fog going this route. Instead of looking for stack you can read books/research by MDs on this topic as well (Brain Maker and Second Brain are two books I recommend).

Make your own kefir at home. Doing so is 100x more potent than any probiotic you can buy online. If done correctly, you should have 50 different strains of bacteria and 2.5 trillion organisms per cup. All you have to do is buy the kefir grains once and the stuff is self-sustaining. Eat fermented foods, low carb, and low sugar.

I wouldn't talk about this if I didn't read science and myriad anecdotes about the efficacy of this route. Good luck. I understand any skepticism that may come my way and will be happy to provide more info.
The moclo/selegiline combo is amazing for energy... The moclo will help the pain (i know that isnt what u were asking about) and the selegiline is a stimulant.. But its not a stimulant like an amphetamine (in the way that it fucks u up) its nice clean clear energy
High dose Omega 3's is the thing to load up on. Hyaluronic Acid might be helpful along with that MSM, but depends on the person. As far as heavier duty things, I hear some people have success with Low Dose Naltrexone, google about and there are tons of testimonials from people with fibromyalgia and MS.
Thiamine helps fibro in clinical studies. Sulbutiamine is a modified version of Thiamine and is a Nootropic that may help the OP.
I had/still have fibromyalgia pain from Lyme & co-infection. For me, herbs like Japanese knotweed, Cats claw and Triphala works well which treats the infections in the digestive system. Your cause of pain maybe different so this may not help you. In terms of noots, yes Sulbutiamine helps. Magnesium maleate and Vitamin D stack as supplements also seem to helps. For pain control, I prefer kratom. I use it very rarely because of its potential for addiction. Healthy eating helps a lot in my case. Eliminating allergents like wheat, dairy, nuts and sugar in my case helps. Fibromyalgia has many different causes & hence different treatment options.
Fibromyalgia and Neuropathy pain tend to respond to a lot of the same substances so, I'm on Lyrica for neuropathy. Most of the time it is sufficient but occasionally not and when it is not tianeptine sodium has worked well. I'm giving tianeptine sulfate a try the next time I experience break through pain and see how it compares to tianeptine sodium. I know the onset will be longer but so should be the effective time, probably enough so that one dose will get me through breakthrough pain occurrences.

If you have fibromyalgia you have experienced excessive daytime sleepiness due to it or chronic fatigue syndrome. You should talk to your doctor about Provigil (modafinil). It is a stimulant but different from traditional amphetamines, that has been approved for the treatment of narcolepsy. Studies confirms that Provigil is well tolerated. The common side effects are usually mild in nature and often consist of headaches, nausea, nervousness, anxiety, dizziness and insomnia. Narcolepsy is a sleep disorder that causes people to fall asleep uncontrollably. Not exactly the same as the sleep disorders and fatigue facing people with fibromyalgia or chronic fatigue syndrome. Low dose Provigil (I take 200mg once or twice a day) or it's generic version Modalert may aid your symptoms of fatigue, cognitive impairment, and excessive daytime sleepiness, as well as improve your motivation to get out and exercise. I use it daily and would not be able to get through the day without it. It also helps me focus my thoughts. Should you consider asking our doctor about this medication? I only can say for me, it works.


Man Fibromyalgia is a tough one and I feel bad for anyone who has it. You won't get much luck treating it. However, Kratom can help a lot in dealing with the pain as several others use it for that purpose. Red Veins primarily and also some Greens. 

one guy on /r/nootropics claims he had 7 ayahausca rituals done with a south american shaman and that completely cured him of his fibromyalgia. While there's not much science behind it, if I had something as chronic and painful as Fibromyalgia I'd do anything.

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