Selegiline its probably my favourite life extension drug.Taken consistently at low dosage selegiline tends to extend the life-expectancy of rats by some 20%. Its protective role against age-related memory decline derives at least in part from its protection of hippocampal neurons (in the aging brain). Selegiline is already used successfully to treat canine cognitive dysfunction syndrome in dogs.I personally take Selegiline to boosts cellular production of SOD and catalase, the natural antioxidant enzymes that are depleted in aging.
My current protocol calls for 1,25 mg every day because i am older than 40 and i have depression. (the older u are, the more Selegiline u should take, but it is advisable not to take more than one 5-mg tablet of it a day unless u have the early symptoms of Parkinson's or Alzheimer's disease.
Carbidopa/Levodopa 5mg and 50mg
Cabergoline .25mg twice a week
Baclofen 15mg twice a week
I'd like people to consider the neuroprotective effects of Low Dose Naltrexone. I'm having wonderful success with it as an analgesic, anxiolytic, libido enhancer, (and anecdotally) as a nootropic. Naltrexone is a competitive antagonist with high affinity for the kor and mor opioid receptors. It has affinity for the dor receptor to a lesser extent.
Opioid receptors have been recently found on cytokines, T-cells, as well as other components of the immune system. LDN has been proven to normalize overactive immune systems, as well as fortify immunosuppressed patients. It has shown promise in the treatment of Chron's disease, Lyme disease, and other autoimmune diseases. Sample sizes have been low in some cases, mainly due to insufficient funding and interest for a generic medication. Read more here: http://www.lowdosenaltrexone.org/index.htm…
Its neuroprotective effects extend to Parkinson's and Alzheimer's patients. MS patients have completely stabilized in the overwhelming majority of individuals. LDN has demonstrated an ability to halt progression of and reverse neurodegenerative disease. Read a similar example here:http://www.ncbi.nlm.nih.gov/pubmed/25774010
Finally, LDN acts as an anticarcinogenic and antitumerigenic. Several patients taking LDN have stabilized or shown a decrease in tumor size. Example of this in an animal model: http://www.sciencedirect.com/…/article/pii/S0090825811002708
It appears individuals stop therapy early, forgetting no established pharmaceutical model is in place for LDN. It has become apparent effective dosages can range from the picogram range to the miligram range. I encorage those attempting LDN therapy to experiment with dosages before giving up. Start small and work your way up. A common side effect is insomnia, enduring a week at most. Some patients observe its benefits 4-18 months following chronic administration. Anecodotally, I noticed a benefit within the first few days. I could have also been suffering from the placebo effect.
my father had BOTH Alzheimers and Parkinsons. In both these diseases, dopamine production is reduced. I'm having excellent results with L-Tyrosine, a supplement which is metabolized in the brain as dopamine, Find it.. I'm 63 years old, just can't recommend this stuff more.
LION'S MANE MUSHROOM has been used in traditional Chinese and Japanese medicine for hundreds of years to treat diseases of the heart, liver, kidneys, spleen, and stomach. Lion’s mane mushroom is also thought to improve digestion, strengthen physical condition, and possibly even inhibit the growth of certain cancers. Sometimes referred to as sheep’s head or bear’s head mushroom, or yamabushitake in Japan, the lion’s mane mushroom is a nootropic (or ‘smart drug’) known for increasing nerve growth factor (NGF) levels in the human brain. This hormone has been linked to increased neuronal growth rates and may improve the synaptic plasticity of the brain. Recent studies show that extracts of lion’s mane mushroom may strengthen memory and concentration, and enhance cognitive abilities. NGF is integral to the growth of neurons, the generation of synapses and even the development of new neurons. Most neurons in the brain are formed within the first two years of life, and until recently it was believed that no new neurons develop later in life. However, it is now known that NGF can actually restart this neuron development process. NGF also makes it easier for neurons to form new connections with other neurons, and may improve communication between different hemispheres of the brain. Lion’s mane mushroom may be able to protect against cognitive dysfunction and age-related memory loss, and might eventually be used for helping people with Alzheimer’s disease, Parkinson's disease, dementia, muscular dystrophy, neuronal degeneration, multiple sclerosis, and perhaps even autism. Research is also being conducted into whether or not lion’s mane mushroom could effectively treat obsessive compulsive personality disorder and ADHD. In addition to guarding the nervous system against degeneration, lion’s mane mushroom acts as an immune-modulator (i.e. it stimulates or suppresses inflammation depending on the context) and also helps to regulate both blood sugar and cholesterol levels. The interferons in lion’s mane mushroom seem to be responsible for its wide range of immune boosting, restorative and organ protecting properties. Lion’s mane mushroom is high in iron, potassium, zinc, and selenium, plus amino acids.